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B20679	苦參堿
源葉	分析標(biāo)準(zhǔn)品,HPLC≥98%

英文名：
Matrine

別名：

CAS號(hào)：
519-02-8

分子式：
C₁₅H₂₄N₂O

分子量：
248.36

MDL：
MFCD00210527

核磁/質(zhì)譜：

品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京	數(shù)量	計(jì)量單位	加入購(gòu)物車...
源葉	B20679-20mg	分析標(biāo)準(zhǔn)品,HPLC≥98%	￥80.00元	>10	3	3	2		EA	加入購(gòu)物車
源葉	B20679-100mg	分析標(biāo)準(zhǔn)品,HPLC≥98%	￥280.00元	>10	-	-	-		EA	加入購(gòu)物車

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產(chǎn)品介紹

參考文獻(xiàn)(54篇)

質(zhì)檢證書(shū)(COA)

摩爾濃度計(jì)算器

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介紹：
Matrine (Matridin-15-one) 是一種在槐屬植物中發(fā)現(xiàn)的生物堿，可作為 kappa 阿片受體和 u-受體激動(dòng)劑。Matrine 具有多種藥理作用，包括抗癌、抗氧化應(yīng)激、抗炎和抗凋亡作用，可用于人類非小細(xì)胞肺癌、肝癌、甲狀腺乳頭狀癌和急性腎損傷 (AKI) 等疾病的研究。

熔點(diǎn)： 77 °C

沸點(diǎn)： 396.7 °C at 760 mmHg

比旋光度： (C=1, EtOH)+33

外觀：針狀或棱狀結(jié)晶

溶解性： DMSO : ≥ 50 mg/mL (201.32 mM)

H2O : 20 mg/mL (80.53 mM; Need ultrasonic)

儲(chǔ)存條件： 2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

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52. [3.8] Jinwu Meng et al."The synergy effect of matrine and berberine hydrochloride on treating colibacillosis caused by an avian highly pathogenic multidrug-resistant Escherichia coli."POULTRY SCIENCE.2024 Jul;:104151

51. [2.3] Meng Jinwu et al."Reversal of gentamicin sulfate resistance in avian pathogenic Escherichia coli by matrine combined with berberine hydrochloride."ARCHIVES OF MICROBIOLOGY.2024 Jul;206(7):1-14

50. [IF=7.5] Xue Li et al."Matrine induces autophagic cell death by triggering ROS/AMPK/mTOR axis and apoptosis in multiple myeloma."BIOMEDICINE & PHARMACOTHERAPY".2024 Jun;175:116738

49. [IF=5] Ruiyang Jiang et al."Sophocarpine alleviates intestinal fibrosis via inhibition of inflammation and fibroblast into myofibroblast transition by targeting the Sirt1/p65 signaling axis."EUROPEAN JOURNAL OF PHARMACOLOGY".2024 Mar;967:176318

48. [IF=5.2] Zhao Jingchao et al."Matrine reverses the resistance of Haemophilus parasuis to cefaclor by inhibiting the mutations in penicillin-binding protein genes (ftsI and mrcA)."Frontiers in Microbiology".2024 Feb;15:

47. [IF=10] Congyan Liu et al."A Sustainable Retinal Drug Co-Delivery for Boosting Therapeutic Efficacy in wAMD: Unveiling Multifaceted Evidence and Synergistic Mechanisms."Advanced Healthcare Materials".2024 Mar;:2303659

46. [IF=5.4] Xinxin Wu et al."The therapeutic efficacy and mechanism action of Si Cao formula in the treatment of psoriasis: A pilot clinical investigation and animal validation."JOURNAL OF ETHNOPHARMACOLOGY.2024 Apr;323:117662

45. [IF=5] Menghan Li et al."Therapeutic deep eutectic solvents based on natural product matrine and caprylic acid: Physical properties, cytotoxicity and formation of surfactant free microemulsion."JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY.2023 Dec;90:105177

44. [IF=4.6] Wei Shijie et al."MAT as a promising therapeutic strategy against triple-negative breast cancer via inhibiting PI3K/AKT pathway."Scientific Reports.2023 Jul;13(1):1-12

43. [IF=4.7] Chen Zihan et al."Liquid chromatography-tandem mass spectrometry analysis of a ratio-optimized drug pair of Sophora flavescens Aiton and Coptis chinensis Franch and study on the mechanism of anti-colorectal cancer effect of two alkaloids thereof."Frontier

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41. [4.462] Zheng Sun et al."Matrine can be absorbed and transmitted bidirectionally to defend against?aphids (Hemiptera: Aphididae) on wheat and pepper."PEST MANAGEMENT SCIENCE.2023 Feb;:

40. [2.13] Xinfeng Chang et al."Matrine inhibits hepatocellular carcinoma cell malignancy through the circ_0013290/miR-139-5p/MMP16 pathway."HISTOLOGY AND HISTOPATHOLOGY.2022 Dec 14;18574

39. [4.966] Yang Li et al."Functional analysis of 3 genes in xenobiotic detoxification pathway of Bursaphelenchus xylophilus against matrine."PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY.2023 Feb;190:105334

38. [IF=3.024] Xuan Yu et al."An innovative extraction strategy for herbal medicine by adopting p-sulphonatocalix[6]/[8]arenes."PHYTOCHEMICAL ANALYSIS

37. [IF=1.978] Chen Ming-jun et al."Composite Sophora Colon-Soluble Capsule Ameliorates DSS-Induced Ulcerative Colitis in Mice via Gut Microbiota-Derived Butyric Acid and NCR+ ILC3."Chin J Integr Med. 2022 Apr;:1-10

36. [IF=5.165] Juanning Ren et al."Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement."Arab J Chem. 2022 Jun;15:103825

35. [IF=2.1] Jikun Du et al."Matrine exerts anti?breast cancer activity by mediating apoptosis and protective autophagy via the AKT/mTOR pathway in MCF?7 cells."Mol Med Rep. 2020 Nov;22(5):3659-3666

34. [IF=2.447] Guanglei Wang et al."Matrine ameliorates the inflammatory response and lipid metabolism in vascular smooth muscle cells through the NF?κB pathway."Exp Ther Med. 2021 Nov;22(5):1-8

33. [IF=4.268] Qing Zhao et al."The water extract of Sophorae tonkinensis Radix et Rhizoma alleviates non-alcoholic fatty liver disease and its mechanism."Phytomedicine. 2020 Oct;77:153270

32. [IF=4.932] Sihao Zheng et al."Combination of matrine and tacrolimus alleviates acute rejection in murine heart transplantation by inhibiting DCs maturation through ROS/ERK/NF-κB pathway."Int Immunopharmacol. 2021 Dec;101:108218

31. [IF=1.448] Wang Xie et al."Matrine inhibits the proliferation and migration of lung cancer cells through regulation of the protein kinase?B/glycogen synthase kinase?3β signaling pathways."Exp Ther Med. 2018 Aug;16(2):723-729

30. [IF=3.943] Kangfeng Jiang et al."Matrine alleviates Staphylococcus aureus lipoteichoic acid-induced endometritis via suppression of TLR2-mediated NF-κB activation."Int Immunopharmacol. 2019 May;70:201

29. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884

28. [IF=5.81] Shang Xiaofei et al."The Anti-diarrheal Activity of the Non-toxic Dihuang Powder in Mice."Front Pharmacol. 2018 Sep;0:1037

27. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084

26. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084

25. Zhang, Qijiayu, et al. "Combination of Berberine and Matrine Affects Apoptosis and Cellcycle in Human Cervical Cancer Cells." Acta Poloniae Pharmaceutica-Drug Research 76.6 (2019): 1089-1097.http://dx.doi.org/10.32383/appdr/112478

24. Diao, Jian, et al. "Bioinformatics analysis of structure and function in the MRP gene family and its expression in response to various drugs in Bursaphelenchus xylophilus." Journal of Forestry Research 32.2 (2021): 779-787.https://doi.org/10.1007/s11676-01

23. Jiang, Kangfeng, et al. "Matrine alleviates Staphylococcus aureus lipoteichoic acid-induced endometritis via suppression of TLR2-mediated NF-κB activation."?International immunopharmacology?70 (2019): 201-207.https://doi.org/10.1016/j.intimp.2019.02.033

22. 鄭榮芳,劉偉,張蕓中,樊學(xué)芬,郭鈺珍.苦參堿調(diào)控Wnt/β-catenin途徑抑制宮頸癌細(xì)胞系Caski細(xì)胞侵襲遷移[J].南京醫(yī)科大學(xué)學(xué)報(bào)(自然科學(xué)版),2021,41(01):35-40.

21. 陽(yáng)麗梅,陳淑芳,黃旭慧,莊捷.苦參堿調(diào)控PXR-CYP3A4通路對(duì)石膽酸誘導(dǎo)肝損傷細(xì)胞系的保護(hù)作用[J].中國(guó)藥學(xué)雜志,2020,55(21):1802-1806.

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19. 程明剛,肖若蕾,袁侶明,程夢(mèng)玲,余海峰.苦參堿脂質(zhì)體凝膠的含量測(cè)定[J].湖北科技學(xué)院學(xué)報(bào)(醫(yī)學(xué)版),2020,34(06):464-466.

18. 李旭,陳嵐,岳園,于軍.苦參堿對(duì)肝癌細(xì)胞HepG2生長(zhǎng)凋亡的作用及機(jī)制[J].中國(guó)老年學(xué)雜志,2020,40(18):3944-3947.

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6. 古月瑜, 廖曉忠, 劉嘉輝,等. 苦參堿對(duì)人孕烷X受體介導(dǎo)的CYP3A4調(diào)節(jié)及藥物相互作用分析.

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1. 陳天朝于蘭蘭劉瑞霞等. 不同物料參數(shù)及配比對(duì)模型丸劑體外溶出的影響[J]. 中華中醫(yī)藥學(xué)刊 2017 035(011):2899-2902.