• 介紹：

   Notoginsenoside R1 (Sanchinoside R1)，是一種從 P. notoginseng 中分離出來的皂苷。 Notoginsenoside R1 具有抗氧化，抗炎，抗血管生成和抗凋亡的活性。Notoginsenoside R1 可提供抗缺血/再灌注 (I/R) 損傷的心臟保護(hù)作用。Notoginsenoside R1 還可以提供神經(jīng)保護(hù)作用。

• 熔點(diǎn)： 215-217°C

• 沸點(diǎn)： 1010.5 °C at 760 mmHg

• 比旋光度： (c, 1.0 in MeOH)+15

• 外觀： 白色粉末

• 溶解性： DMSO  :  100  mg/mL  (107.17  mM;  Need  ultrasonic)

• 敏感性： 易吸潮

• 儲(chǔ)存條件： 2-8℃

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

• 73. [6.1] Yuan Li et al."Notoginsenoside R1 decreases intraplaque neovascularization by governing pericyte-endothelial cell communication via Ang1/Tie2 axis in atherosclerosis."PHYTOTHERAPY RESEARCH.2024 Jun;:

• 72. [6.8] Yun Zhao et al."The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination."BRITISH JOURNAL OF PHARMACOLOGY.2024 Sep;:

• 71. [3.3] Rong Liu et al."Characterization of a Xylosyltransferase from Panax notoginseng Catalyzing Ginsenoside 2′-O Glycosylation in the Biosynthesis of Notoginsenosides."JOURNAL OF NATURAL PRODUCTS.2024;XXXX(XXX):XXX-XXX

• 70. [IF=4.8] Liying Ma et al."Notoginsenoside R1 Ameliorate High-Fat-Diet and Vitamin D3-Induced Atherosclerosis via Alleviating Inflammatory Response, Inhibiting Endothelial Dysfunction, and Regulating Gut Microbiota."Drug Design Development and Therapy.10.2147/DDDT.

• 69. [IF=8.6] Minghui Li et al."Natural deep eutectic solvents-based selective extraction of saponins from Panax notoginseng: Process optimization, chemical profiling, and bioactivities evaluation."SEPARATION AND PURIFICATION TECHNOLOGY".2024 Aug;341:126882

• 68. [IF=2.6] Wan Min et al."Suppression of JAK2/STAT3 Pathway by Notoginsenoside R1 Reduces Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer."MOLECULAR BIOTECHNOLOGY".2024 Apr;:1-13

• 67. [IF=2.7] Wenjie Su et al."Therapeutic effect of notoginseng saponins before and after fermentation on blood deficiency rats."Experimental and Therapeutic Medicine".2024 Apr;27(4):1-16

• 66. [IF=8.8] Haiyang Li et al."Research on rapid quality identification method of Panax notoginseng powder based on artificial intelligence sensory technology and multi-source information fusion technology."FOOD CHEMISTRY.2024 May;440:138210

• 65. [IF=3.5] Zhu Cun et al."Integrated metabolome and transcriptome analysis reveals the regulatory mechanism of low nitrogen-driven biosynthesis of saponins and flavonoids in Panax notoginseng."GENE.2024 Jan;:148163

• 64. [IF=5.4] Yingqiu Shi et al."Effective constituents and protective effect of Mudan granules against Schwann cell injury."JOURNAL OF ETHNOPHARMACOLOGY.2024 Apr;323:117692

• 63. [IF=3.4] Xiaonan Wang et al."Notoginsenoside R1 ameliorates the inflammation induced by amyloid?β by suppressing SphK1?mediated NF?κB activation in PC12 cells."Molecular Medicine Reports.2024 Jan;29(1):1-11

• 62. [IF=3.7] Xiaoxian Pei et al."Notoginsenoside R1 attenuates brain injury in rats with traumatic brain injury: Possible mediation of apoptosis via ERK1/2 signaling pathway."PLoS One.2023 Dec;18(12):e0295903

• 61. [IF=4.8] Guozhuang Zhang et al."Rhizosphere effects on the microbial community: Specificity and conservatism across geographically disjunct Panax species."APPLIED SOIL ECOLOGY.2023 Dec;192:105075

• 60. [IF=7.9] Zhang Guozhuang et al."Modules in robust but low-efficiency phyllosphere fungal networks drive saponin accumulation in leaves of different Panax species."Environmental Microbiome.2023 Dec;18(1):1-15

• 59. [IF=4.546] Xu Ying et al."Panax notoginseng saponins inhibits NLRP3 inflammasome-mediated pyroptosis by downregulating lncRNA-ANRIL in cardiorenal syndrome type 4."Chinese Medicine.2023 Dec;18(1):1-13

• 58. [IF=6.388] He Zhang et al."Prevention effect of total ginsenosides and ginseng extract from Panax ginseng on cyclophosphamide-induced immunosuppression in mice."PHYTOTHERAPY RESEARCH.2023 Apr;:

• 57. [4.927] Junchen Liu et al."Anti-Inflammatory Activity of Panax notoginseng Flower Saponins Quantified Using LC/MS/MS."MOLECULES.2023 Jan;28(5):2416

• 56. [6.449] Na Li et al."β-Xylosidase mutant immobilization on UiO-66-NH2 for continuous production of ginsenoside Rg1 and selective production of furfural from notoginsenoside R1."INDUSTRIAL CROPS AND PRODUCTS.2023 Jul;197:116563

• 55. [6.656] Linying Xia et al."Panax notoginseng saponins normalises tumour blood vessels by inhibiting EphA2 gene expression to modulate the tumour microenvironment of breast cancer."PHYTOMEDICINE.2023 Mar;:154787

• 54. [3.061] Zhu Cun et al."High nitrogen inhibits biomass and saponins accumulation in a medicinal plant Panax notoginseng."PeerJ.2023 Feb;11:e14933

• 53. [3.945] Linlin Su et al."Development of SSR markers on the basis of the Panax notoginseng transcriptome for agronomic and biochemical trait association analyses."Journal of Applied Research on Medicinal and Aromatic Plants.2023 Apr;34:100475

• 52. [14.026] Junyun Cheng et al."High-throughput transcriptional profiling of perturbations by Panax ginseng saponins and Panax notoginseng saponins using TCM-seq."Journal of Pharmaceutical Analysis.2023 Feb;:

• 51. [4.927] Hong-Ping Wang et al."Comprehensive Identification of Ginsenosides in the Roots and Rhizomes of Panax ginseng Based on Their Molecular Features-Oriented Precursor Ions Selection and Targeted MS/MS Analysis."MOLECULES.2023 Jan;28(3):941

• 50. [4.036] Hongping Wang et al."Improving natural products identification through molecular features-oriented precursor ion selection and targeted MS/MS analysis: a case study of Zhi-Ke-Yang-Yin capsule."RSC Advances.2022 Nov;12(51):33340-33347

• 49. [IF=0] Hong Kan et al."Identification of anti-inflammatory components in Panax ginseng of Sijunzi Decoction based on spectrum-effect relationship."Chinese Herbal Medicines.2022 Oct;:

• 48. [IF=5.988] Mengwen Huang et al."Discovering the potential active ingredients of Qi-Yu-San-Long decoction for anti-oxidation, inhibition of non-small cell lung cancer based on the spectrum-effect relationship combined with chemometric methods.."Frontiers in Pharmacol

• 47. [IF=2.893] Zhong Peng et al."Characterization of a novel thermophilic beta-glucosidase from Thermotoga sp. and its application in the transformation of notoginsenoside R1."3 Biotech.2022 Nov;12(11):1-14

• 46. [IF=6.449] Na Li et al."Enhanced conversion and extraction of ginsenoside Rg1 from Panax notoginseng using β-xylosidase mutants and an endoxylanase."INDUSTRIAL CROPS AND PRODUCTS.2022 Nov;187:115514

• 45. [IF=3.318] Hongda Sheng et al."Identification of bioactive ingredients from Babaodan using UPLC-QTOF-MS analysis combined with network pharmacology guided bioassays."JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES.2022 Aug;120

• 44. [IF=5.811] He Zhang et al."Prevention Effect of Protopanaxadiol-Type Saponins Saponins and Protopanaxatriol-Type Saponins on Myelosuppression Mice Induced by Cyclophosphamide.."Frontiers in Pharmacology. 2022 Apr;13:845034-845034

• 43. [IF=3.373] Yu Yao et al."UPLC–MS/MS method for the determination of the herb composition of Tangshen formula and the in vivo pharmacokinetics of its metabolites in rat plasma."Phytochemical Analysis. 2021 Dec 14

• 42. [IF=1.978] Wang Rong-rong et al."Acute Developmental Toxicity of Panax notoginseng in Zebrafish Larvae."Chin J Integr Med. 2022 Jan;:1-8

• 41. [IF=4.411] Xuanming Zhang et al.Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of Panax quinquefolius from Wendeng, China.Molecules. 2021 Jan;26(22):6829

• 40. [IF=3.199] Li Yuan et al."In Vitro Anti-hepatoma Activities of Notoginsenoside R1 Through Downregulation of Tumor Promoter miR-21."Digest Dis Sci. 2020 May;65(5):1364-1375

• 39. [IF=3.205] Jie Tang et al."Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."J Chromatogr B. 2021 Aug;1179:122827

• 38. [IF=3.503] Jiajia Dong et al."Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins."Pharm Biol. 2021;59(1):653-661

• 37. [IF=3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju

• 36. [IF=3.69] Tianyuan Yu et al."Anti-inflammation effect of Qingchang suppository in ulcerative colitis through JAK2/STAT3 signaling pathway in vitro and in vivo."J Ethnopharmacol. 2021 Feb;266:113442

• 35. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328

• 34. [IF=3.932] Bo Cao et al."Protective effects of notoginsenoside R1 on acute lung injury in rats with sepsis."Ann Transl Med. 2021 Jun; 9(12): 996

• 33. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206

• 32. [IF=4.142] Wang Chenxi et al."Rapid discovery of potential ADR compounds from injection of total saponins from Panax notoginseng using data-independent acquisition untargeted metabolomics."Analytical And Bioanalytical Chemistry. 2021 Oct 26

• 31. [IF=4.162] Weixin Hou et al."The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats."Drug Des Dev Ther. 2021; 15: 3845–3862

• 30. [IF=4.36] Yongshen Ren et al."Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational analysis combined with UPLC-MS and molecular docking."J Ethnopharmacol. 2020 Oct;260:112955

• 29. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625

• 28. [IF=5.34] Gui Zhou et al."Effects of Qing Chang Suppository Powder and its Ingredients on IL-17 Signal Pathway in HT-29 Cells and DSS-induced Mice."Phytomedicine. 2021 Jul;87:153573

• 27. [IF=5.81] Xiaoyu Liu et al."Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway."Front Pharmacol. 2021; 12: 687394

• 26. [IF=0] Dingkun Gui et al."Notoginsenoside R1 Ameliorates Podocyte Adhesion Under Diabetic Condition Through α3β1 Integrin Upregulation in Vitro and in Vivo."Cell Physiol Biochem. 2014;34(6):1849-1862

• 25. [IF=3.575] Ting Wang et al."Notoginsenoside R1 stimulates osteogenic function in primary osteoblasts via estrogen receptor signaling."Biochem Bioph Res Co. 2015 Oct;466:232

• 24. [IF=4.213] Qiangyuan Fan et al."Improved oral bioavailability of notoginsenoside R1 with sodium glycocholate-mediated liposomes: Preparation by supercritical fluid technology and evaluation in vitro and in vivo."Int J Pharmaceut. 2018 Dec;552:360

• 23. [IF=6.06] Yang Xiu et al."Simultaneous determination and difference evaluation of 14 ginsenosides in Panax ginseng roots cultivated in different areas and ages by high-performance liquid chromatography coupled with triple quadrupole mass spectrometer in the multipl

• 22. Bian, Minjuan, et al. "Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration." Scientific reports 7.1 (2017): 1-15.https://doi.org/10.1038/s41598-017-06471-x

• 21. Yongshen Ren, Jiao Ai, Xinqiao Liu, Shuai Liang, Yao Zheng, Xin Deng, Yan Li, Jing Wang, Xukun Deng, Lin-Lin Chen, Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational anal

• 20. GUI, Dingkun, et al. Notoginsenoside R1 ameliorates podocyte adhesion under diabetic condition through α3β1 integrin upregulation in vitro and in vivo. Cellular Physiology and Biochemistry, 2014, 34.6: 1849-1862.https://doi.org/10.1159/000366384

• 19. Ting Wang, Daqian Wan, Lei Shao, Jiezhi Dai, Chaoyin Jiang, Notoginsenoside R1 stimulates osteogenic function in primary osteoblasts via estrogen receptor signaling, Biochemical and Biophysical Research Communications, Volume 466, Issue 2, 2015, Pages 232-

• 18. 樂世俊,王文曉,高歡,任繼國,付瑞嘉,李佳佳,陳艷琰,唐于平.HPLC同時(shí)測定不同廠家丹七片中多個(gè)有效成分的含量[J].藥物分析雜志,2020,40(12):2236-2243.

• 17. 杜靜. 冠突散囊菌對(duì)中藥材三七成分的轉(zhuǎn)化及機(jī)理研究[D].貴州師范大學(xué),2020.

• 16. 吳雨佳, 王令充, 張雯,等. 生物黏附性三七總皂苷-白及多糖-海藻酸鈉復(fù)合微球的制備及表征[J]. 中草藥, 2019, v.50;No.655(20):49-56.

• 15. 張永 陳旭 丁越 等. HPLC法結(jié)合統(tǒng)計(jì)學(xué)方法研究復(fù)方丹參片中皂苷類成分[J]. 遼寧中醫(yī)雜志 2019 46(01):126-129.

• 14. 劉芳, 趙瀚森, 孫公偉,等. 基質(zhì)輔助激光解析質(zhì)譜成像可視化分析三七皂苷空間分布.

• 13. 于穎超, 倪健, 陳功森,等. 芪箭顆粒中皂苷類成分與莫諾苷的指紋圖譜研究[J]. 中南藥學(xué), 2019(12).

• 12. 孫孔春 吳樂艷 侯雯清 等. 云南省不同產(chǎn)地三七的成分分析[J]. 昆明醫(yī)科大學(xué)學(xué)報(bào) 2020 041(001):P.1-10.

• 11. 袁明洋 金司儀 黃壯 等. 不同粒度對(duì)三七粉主要有效成分體外溶出度的影響[J]. 食品安全質(zhì)量檢測學(xué)報(bào) 2020 v.11(06):234-238.

• 10. 吳朕 茹金 樊楚明 等. 三七皂苷R1保護(hù)四氯化碳誘導(dǎo)肝纖維化模型大鼠的作用[J]. 中國組織工程研究 2020 024(026):4213-4217.

• 9. 劉夢(mèng)楠 薛雪 熊慧 等. 不同凈制工藝對(duì)三七質(zhì)量的影響[J]. 世界中醫(yī)藥 2019 v.14(02):56-59+64.

• 8. 韓柱, 崔波, 陸菁,等. 清腸栓質(zhì)量標(biāo)準(zhǔn)研究[J]. 中成藥, 2016, 38(008):1749-1753.

• 7. 劉夢(mèng)楠 王敏 白玉瑩 等. 包裝對(duì)三七粉和熟三七粉穩(wěn)定性的影響研究[J]. 世界中醫(yī)藥 2020年15卷13期 1891-1896頁 ISTIC 2020.

• 6. 趙志新 胡小銘 汪杰 柴海飛.三七皂苷R_1對(duì)大鼠腦缺血-再灌注損傷后TNF-α mRNA的影響[J].浙江創(chuàng)傷外科 2017 22(01):13-16.

• 5. 熊敏琪 陳瑜 張騰. 三七皂苷R1抑制ApoE基因敲除小鼠肝臟脂質(zhì)沉積的作用及其機(jī)制研究[J]. 上海中醫(yī)藥雜志 2018 v.52；No.580(05):71-76.

• 4. 普顯宏 何媛 黃微 茹金 楊金偉.三七皂苷R1對(duì)肝纖維化大鼠TGF-β1/Smad3信號(hào)的影響[J].現(xiàn)代生物醫(yī)學(xué)進(jìn)展 2015 15(04):622-626.

• 3. 任民 徐革 彭偉 何吉洪 陳和平.三七皂苷R1對(duì)缺氧誘導(dǎo)PC12細(xì)胞損傷的保護(hù)作用[J].中國臨床藥理學(xué)雜志 2020 36(12):1657-1660.

• 2. 楊丹 姜嵐 黃娟 等. 三七皂苷R1-PLGA納米微球的制備及優(yōu)化研究[J]. 化學(xué)與粘合 2020 v.42;No.190(02):16-19+23.

• 1. 楊丹 姜嵐 朱梅 等. PLGA攜三七皂苷Rb1微球的制備及實(shí)驗(yàn)條件優(yōu)化研究[J]. 中國醫(yī)學(xué)創(chuàng)新 2020 017(003):151-154.

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *