• 介紹：

  Scutellarin 是從黃芩中分離到的黃酮類物質(zhì)，在 HCC 細(xì)胞中，能夠下調(diào) STAT3/Girdin/Akt 信號(hào)通路，在破骨細(xì)胞中，能夠抑制 RANKL 介導(dǎo)的 MAPK/NF-κB 信號(hào)通路。Scutellarin 具有抗 HIV-1IIIB，HIV-1(74V) 和 HIV-1KM018 的活性，EC₅₀ 分別為 26 μM，253 μM 和 136 μM。

• 熔點(diǎn)： 300-301°C

• 沸點(diǎn)： 891.6°C at 760 mmHg

• 比旋光度： -14°(水)，-139°(吡啶)

• 外觀： 黃色針狀結(jié)晶

• 溶解性： DMSO  :  100  mg/mL  (216.28  mM;  Need  ultrasonic)

• 儲(chǔ)存條件： 2-8℃

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

• 45. [5.6] Chunte Feng et al."Rosmarinic acid separation from Perilla frutescens leaf extract utilizing acid-resistant magnetic molecularly imprinted polymers with boronate affinity."INDUSTRIAL CROPS AND PRODUCTS.2024 Dec;222:119582

• 44. [4.2] Ting Lu et al."18β-Glycyrrhetinic acid synergizes with enzalutamide to counteract castration-resistant prostate cancer by inhibiting OATP2B1 uptake of dehydroepiandrosterone."EUROPEAN JOURNAL OF PHARMACOLOGY.2024 Sep;:176995

• 43. [4.8] Tao Yuan et al."Scutellarin inhibits inflammatory PANoptosis by diminishing mitochondrial ROS generation and blocking PANoptosome formation."INTERNATIONAL IMMUNOPHARMACOLOGY.2024 Sep;139:112710

• 42. [IF=7.9] Yanqin Luo et al."Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota."PHYTOMEDICINE".2024 May;:155706

• 41. [IF=4.6] Wei Yang et al."Synthesis and In Vivo Antiarrhythmic Activity Evaluation of Novel Scutellarein Analogues as Voltage-Gated Nav1.5 and Cav1.2 Channels Blockers."MOLECULES.2023 Jan;28(21):7417

• 40. [IF=3.4] Zhen Ma et al."Identification of chemical compounds of Schizonepeta tenuifolia Briq. and screening of neuraminidase inhibitors based on AUF-MS and SPR technology."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2024 Jan;237:115787

• 39. [IF=5.4] Yuming Yang et al."Taohong Siwu decoction reduces acute myocardial ischemia–reperfusion injury by promoting autophagy to inhibit pyroptosis."JOURNAL OF ETHNOPHARMACOLOGY.2024 Mar;321:117515

• 38. [IF=4.3] Bao-Fei Yan et al."Huangqin decoction alleviates lipid metabolism disorders and insulin resistance in nonalcoholic fatty liver disease by triggering Sirt1/NF-κB pathway."WORLD JOURNAL OF GASTROENTEROLOGY.2023 Aug 21; 29(31): 4744–4762

• 37. [5.195] Fuda Xie et al."Pathway network-based quantitative modeling of the time-dependent and dose-response anti-inflammatory effect of Reduning Injection."JOURNAL OF ETHNOPHARMACOLOGY.2023 May;307:116216

• 36. [IF=5.195] Weicong Chen et al."Biejiajian pill inhibits progression of hepatocellular carcinoma by downregulating PDGFRβ signaling in cancer-associated fibroblasts."JOURNAL OF ETHNOPHARMACOLOGY.2022 Oct;:115825

• 35. [IF=5.195] Xin Deng et al."A novel strategy for active compound efficacy status identification in multi-tropism Chinese herbal medicine (Scutellaria baicalensis Georgi) based on multi-indexes spectrum-effect gray correlation analysis."JOURNAL OF ETHNOPHARMACOLOGY.20

• 34. [IF=6.208] Pan Wang et al."Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure–Activity Relationship and Inhibition Profiles."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022 Jan;23(18):10747

• 33. [IF=3.614] Huanyu Guan et al."Deciphering the chemical constituents of Shengjiang Xiexin decoction by ultra-high-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry and the impact of 20 characteristic components on multidrug resis

• 32. [IF=5.195] Mengmeng Song et al."Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents."JOURNAL OF ETHNOPHARMACOLOGY.2022 Jul;:115545

• 31. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155

• 30. [IF=3.935] Yizhu Wang et al."Effects of Scutellaria baicalensis Georgi. on Intestinal Flora in Rats with Spleen Deficiency and Damp-heat."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114831

• 29. [IF=1.448] Xiaoqin Zhong et al."Scutellarin?treated exosomes increase claudin 5, occludin and ZO1 expression in rat brain microvascular endothelial cells."Exp Ther Med. 2019 Jul;18(1):33-40

• 28. [IF=1.552] Fang Mingyue et al."Qualitative and Quantitative Analysis of 24 Components in Jinlianhua Decoction by UPLC–MS/MS."Chromatographia. 2019 Dec;82(12):1801-1825

• 27. [IF=2.952] Shao-Hua Ju et al."Scutellarin regulates osteoarthritis in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway."Mol Med Rep. 2021 Jan;23(1):1-1

• 26. [IF=3.361] Fuen Liu et al."Scutellarin ameliorates cartilage degeneration in osteoarthritis by inhibiting the Wnt/β-catenin and MAPK signaling pathways."Int Immunopharmacol. 2020 Jan;78:105954

• 25. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328

• 24. [IF=3.935] Meng Chen et al."Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate."J Pharmaceut Biomed. 2021 Feb;195:113820

• 23. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra

• 22. [IF=5.11] Xiaonan Liu et al."De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae."Acs Synth Biol. 2020;9(11):3042–3051

• 21. [IF=5.34] Shusheng Fan et al."Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS."Phytomedicine. 2021 Oct;91:153673

• 20. [IF=6.023] Ying Liu et al."Mechanistic study of bergamottin-induced inactivation of CYP2C9."Food Chem Toxicol. 2021 Jul;153:112278

• 19. [IF=7.097] Jiezhou Ye et al."Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling."Acta Pharm Sin B. 2021 Jan;11:112

• 18. [IF=1.851] Xinyu Hu et al."Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis."Mol Med Rep. 2018 Nov;18(5):4289-4296

• 17. [IF=1.902] Yining Zhao et al."Simultaneous quantitation of 23 bioactive compounds in Tanreqing capsule by high-performance liquid chromatography electrospray ionization tandem mass spectrometry."Biomed Chromatogr. 2019 Jul;33(7):e4531

• 16. [IF=2.146] Wei-Wei Wang et al."Scutellarin may alleviate cognitive deficits in a mouse model of hypoxia by promoting proliferation and neuronal differentiation of neural stem cells."Iran J Basic Med Sci. 2017 Mar; 20(3): 272–279

• 15. [IF=2.678] Wang Wei-Wei et al."Scutellarin Alleviates Behavioral Deficits in a Mouse Model of Multiple Sclerosis, Possibly Through Protecting Neural Stem Cells."J Mol Neurosci. 2016 Feb;58(2):210-220

• 14. [IF=3.046] Liwei Dong et al."Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1."Oncotargets Ther. 2015; 8: 3649–3664

• 13. [IF=3.361] Huanyu Guan et al."Comparative intestinal bacteria-associated pharmacokinetics of 16 components of Shengjiang Xiexin decoction between normal rats and rats with irinotecan hydrochloride (CPT-11)-induced gastrointestinal toxicity in vitro using salting-out

• 12. [IF=3.935] Liangmian Chen et al."Simultaneous determination of various bioactive redox components in Shuang–Huang–Lian preparations using a novel three-channel isocratic elution liquid chromatography with electrochemical detection system."J Pharmaceut Biomed. 2014 J

• 11. Chen, Meng, et al. "Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate." Journal of Pharmaceutical and Biomedical Analysis 195 (2021): 113820.https://

• 10. Wang, WW., Lu, L., Bao, TH. et al. Scutellarin Alleviates Behavioral Deficits in a Mouse Model of Multiple Sclerosis, Possibly Through Protecting Neural Stem Cells. J Mol Neurosci 58, 210–220 (2016). https://doi.org/10.1007/s12031-015-0660-0

• 9. 紀(jì)萬(wàn)里,周澤華,王婷婷,安叡,梁琨,王新宏.基于UPLC-LTQ-Orbitrap-MS方法分析半夏瀉心湯化學(xué)成分[J].藥物分析雜志,2020,40(10):1736-1750.

• 8. 蔣家璐,孫溧,倪姐,徐墜成,宋蒙蒙,姚衛(wèi)峰,程海波,康安,孫東東.腸道菌群對(duì)半枝蓮中活性成分的代謝及其抑制CYP1A1酶的影響[J].南京中醫(yī)藥大學(xué)學(xué)報(bào),2021,37(02):225-230.

• 7. 路東波, 高園園, 姜艷艷,等. 基于有效基準(zhǔn)特征圖譜質(zhì)量表征模式的中藥紫蘇葉質(zhì)量評(píng)價(jià)研究[J]. 北京中醫(yī)藥大學(xué)學(xué)報(bào), 2020, 043(002):148-162.

• 6. 柯小紅. 多裂翅果菊中菊苣酸的分離純化與微生物轉(zhuǎn)化[D].南京師范大學(xué),2015.

• 5. 宋軍妹, 惠權(quán)斌, 呂文英,等. 銀丹心腦通軟膠囊定量質(zhì)量控制提升研究[J]. 中國(guó)現(xiàn)代中藥, 2017(10):1466-1469.

• 4. 范書(shū)生, 李想, 孫思琪,等. 百里香酚類部位HPLC和UV-Vis法含量測(cè)定方法研究[J]. 北京中醫(yī)藥大學(xué)學(xué)報(bào), 2019, 042(010):854-861.

• 3. 徐雪林, 趙潔, 易紅,等. 燈盞乙素乙酯原料藥中主成分含量測(cè)定及其有關(guān)物質(zhì)研究[J]. 中國(guó)藥學(xué)雜志, 2015, 50(18):1581-1588.

• 2. 熊華斌, 阿新祥, 楊欣雨,等. 正交設(shè)計(jì)在燈盞乙素提取優(yōu)化中的應(yīng)用[J]. 北方園藝, 2013(06):164-166.

• 1. 田宇柔[1 3 4] 甄亞欽[1 3 4] 王鑫國(guó)[1 3 4] 李軍山[2 3 4] 牛麗穎[1 3 4]. 半枝蓮配方顆粒HPLC指紋圖譜及含量測(cè)定方法研究[J]. 中國(guó)藥學(xué)雜志 2016(51):1799.

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *