• 產(chǎn)品描述：

  ZAP-180013 是一種 ZAP-70 抑制劑，IC50 為 1.8 μM。ZAP-180013 抑制 ZAP-70 SH2 結(jié)構(gòu)域與基于免疫受體酪氨酸的激活基序 (ITAM) 的相互作用。
   

• 靶點(diǎn)： ZAP-70;TyrosineKinases;Tyrosinase

• 體外研究：
  ZAP-70 is a critical molecule in the transduction of T cell antigen receptor signaling and the activation of T cells. Upon activation of the T cell antigen receptor, ZAP-70 is recruited to the intracellular ζ-chains of the T cell receptor, where ZAP-70 is activated and colocalized with its substrates. Inhibitors of ZAP-70 could potentially function as treatments for autoimmune diseases or organ transplantation. ZAP-180013 disrupts the interaction between ZAP-70 and the T cell antigen receptor. The IC50s in both FP and TR-FRET assays for ZAP-180013 are 9.6 μM and 16.841 μM, respectively[1].

• 參考文獻(xiàn)：
  [1]. Patrick R Visperas, et al. Identification of Inhibitors of the Association of ZAP-70 With the T Cell Receptor by High-Throughput Screen. SLAS Discov. 2017 Mar;22(3):324-331. [Content Brief]

• 溶解性： DMSO  :  250  mg/mL  (550.26  mM;  Need  ultrasonic)

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.201 ml	11.005 ml	22.01 ml
  5 mM	0.44 ml	2.201 ml	4.402 ml
  10 mM	0.22 ml	1.101 ml	2.201 ml
  50 mM	0.044 ml	0.22 ml	0.44 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *