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• 產(chǎn)品描述： Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity

• 靶點(diǎn)： PI3Kα：0.5 nM (IC50)；PI3Kβ：3.7 nM (IC50)；PI3Kδ：0.7 nM (IC50)；PI3Kγ：6.4 nM (IC50)；mTOR：45 nM (IC50);Apoptosis;PI3K

• 體內(nèi)研究：
  Copanlisib (BAY 80-6946; 0.5-6 mg/kg; intravenous injection; every second day, every third day; for 60 days; athymic nude rats) treatment displays robust antitumor activity in the rat KPL4 tumor xenograft model

• 參考文獻(xiàn)：
  1. Liu N, et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov;12(11):2319-30.

• 溶解性： 1M  HCl  :  100  mg/mL  (208.11  mM;  Need  ultrasonic)

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.081 ml	10.405 ml	20.811 ml
  5 mM	0.416 ml	2.081 ml	4.162 ml
  10 mM	0.208 ml	1.041 ml	2.081 ml
  50 mM	0.042 ml	0.208 ml	0.416 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *