• 產品描述： Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms

• 靶點： Rat D2 Receptor:54 nM (Ki);Rat 5-HT2 Receptor:3.1 nM (Ki);Rat D1 Receptor:546 nM (Ki);Rat 5-HT1A Receptor:168 nM (Ki);Rat 5-HT6 Receptor:42.7 μM (Ki);Rat 5-HT7 Receptor:21.6 nM (Ki);Human D1 Receptor:216 nM (Ki);Human D3 Receptor:7.1 nM (Ki);Human D4 Receptor:25 nM (Ki);Human D5 Receptor:319 nM (Ki);Human 5-HT2A Receptor:5.6 nM (Ki);Human 5-HT2C Receptor:42.8 nM (Ki);DopamineReceptor;5-HTReceptor;AdrenergicReceptor

• 體內研究：
  Iloperidone is eliminated slowly, with a mean t1/2?of 13.5 to 14.0 hours. Coadministration with food did not significantly affect AUC, tmax, or Cmax. These results indicate that the rate of iloperidone's absorption is decreased, but the overall bioavailability is unchanged, when the drug is taken with food. Orthostatic hypotension, dizziness, and somnolence were the most commonly reported adverse events

• 參考文獻：
  1. Kongsamut, S., et al., Iloperidone binding to human and rat dopamine and 5-HT receptors. Eur J Pharmacol, 1996. 317(2-3): p. 417-23. 2. Sainati, S.M., et al., Safety, tolerability, and effect of food on the pharmacokinetics of iloperidone (HP 873), a potential atypical antipsychotic. J Clin Pharmacol, 1995. 35(7): p. 713-20. 3. Albers, L.J., A. Musenga, and M.A. Raggi, Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market? Expert Opin Investig Drugs, 2008. 17(1): p. 61-75.

• 溶解性： Soluble  in  DMSO

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.345 ml	11.724 ml	23.448 ml
  5 mM	0.469 ml	2.345 ml	4.69 ml
  10 mM	0.234 ml	1.172 ml	2.345 ml
  50 mM	0.047 ml	0.234 ml	0.469 ml

• 注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

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本計算器可幫助您計算出特定溶液中溶質的質量、溶液濃度和體積之間的關系，公式為：

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *