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• 產(chǎn)品描述： BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4[1]. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth

• 靶點： GLUT1:2 nM (IC50);GLUT2:10.08 μM (IC50);GLUT3:1.67 μM (IC50);GLUT4;0.29 μM (IC50);transporter

• 體外研究：
  BAY-876 (25-75 nM; 24 and 72 hours) has the growth-inhibitory effect and leads to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells. Cell Proliferation Assay Cell Line: SKOV-3 and OVCAR-3 cells Concentration: 25, 50, 75 nM Incubation Time: 24 and 72 hours Result: Led to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells.

• 體內(nèi)研究：
  BAY-876 (oral administration; 1.5-4.5 mg/kg/day for 28 days) causes a clear dose-dependent inhibition of tumorigenicity in mice. Animal Model: Female NOD-scid IL2rgnull (NSG) mice carrying SKOV-3 subcutaneous (s.c.) xenografts Dosage: 1.5, 3, 4.5 mg/kg Administration: Oral administration; daily; for 28 days Result: Caused a clear dose-dependent inhibition of tumorigenicity.

• 參考文獻：
  1. Siebeneicher H et al. Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem. 2016 Aug 23. 2. Ma Y, et al. Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876. Cancers (Basel). 2018 Dec 31;11(1).

• 溶解性： Soluble  in  DMSO、Methanol

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.014 ml	10.072 ml	20.144 ml
  5 mM	0.403 ml	2.014 ml	4.029 ml
  10 mM	0.201 ml	1.007 ml	2.014 ml
  50 mM	0.04 ml	0.201 ml	0.403 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

• 1. [11.467] Chao Li et al."Core-shell nanosystems designed for effective oral delivery of polypeptide drugs."JOURNAL OF CONTROLLED RELEASE.2022 Dec;352:540

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *