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• 產(chǎn)品描述： GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms

• 靶點(diǎn)： c-Raf:9 nM (IC50);Apoptosis;Raf

• 體內(nèi)研究：
  GW5074 (5 mg/Kg) completely prevents extensive bilateral striatal lesions induced by 3-NP in mice. GW5074 suppresses sidestream smoke-induced airway hyperresponsiveness in mice

• 參考文獻(xiàn)：
  1. Chin PC, et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem, 2004, 90(3), 595-608. 2. Lei Y, et al. The Raf-1 inhibitor GW5074 and NSC 34521 suppress sidestream smoke-induced airway hyperresponsiveness in mice. Respir Res, 2008, 9(1), 71.

• 溶解性： DMSO  :  100  mg/mL  (191.96  mM;  ultrasonic  and  warming  and  heat  to  60°C)

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	1.92 ml	9.598 ml	19.196 ml
  5 mM	0.384 ml	1.92 ml	3.839 ml
  10 mM	0.192 ml	0.96 ml	1.92 ml
  50 mM	0.038 ml	0.192 ml	0.384 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *