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• 產(chǎn)品描述： Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015)在色素內(nèi)鏡檢查中被作用染料。它能抑制tau蛋白絲的形成，IC50為1.9μM，同時還抑制可溶性鳥苷環(huán)化酶

• 靶點： guanylate cyclase; Tau aggregation:1.9 μM;Guanylatecyclase;MicrotubuleAssociated;NOSynthase;Parasite;MonoamineOxidase

• 體外研究：
  Methylene Blue可能抑制NO合成酶或通過產(chǎn)生超氧陰離子，直接使一氧化氮失活。除了干擾一氧化氮換鳥苷酸途徑，Methylene Blue直接激活鈣離子依賴性的鉀通道來增強去甲腎上腺素從細胞內(nèi)的釋放

• 體內(nèi)研究：
  Methylene Blue抑制鳥苷酸環(huán)化酶，減少C-GMP和血管平滑松弛。當(dāng)進行靜脈注射時，亞甲藍在甲狀旁腺積累，從而在外科手術(shù)中借以其顏色來判斷這些內(nèi)部結(jié)構(gòu)。在嚙齒類的藥動學(xué)實驗揭示，血管內(nèi)進行MB給藥將導(dǎo)致MB在中樞神經(jīng)細胞中迅速廣泛的積累

• 細胞實驗： Cell lines: 未成熟的成神經(jīng)細胞 Concentrations: 10 μM Incubation Time: 2 h Method: 從新生大鼠的室管膜下層分離出來的未成熟的成神經(jīng)細胞，在單細胞培養(yǎng)模型中，分化成γ氨基丁酸所介導(dǎo)神經(jīng)元，用此神經(jīng)元細胞用于后續(xù)實驗。在體外實驗中，第6天，用MB對細胞培養(yǎng)物進行處理2h，處理完48小時后，檢測細胞樹突分枝結(jié)構(gòu)及生存情況

• 動物實驗： Animal Models: Sprague- Dawley雄性大鼠 Dosages: 5 and 50 mg/kg Administration: 血管內(nèi)注射

• 參考文獻：
  1. Vutskits L, et al. Adverse effects of methylene blue on the central nervous system. Anesthesiology. 108(4):684-692. 2. Hochgr鋐e K, et al. Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathol Commun. 2015, 3:25. 3. Masaki E, et al. Methylene blue, a soluble guanylyl cyclase inhibitor, reduces the sevoflurane minimum alveolar anesthetic concentration and decreases the brain cyclic guanosine monophosphate content in rats. Anesth Analg. 1999, 89(2):484-489. 4. Ginimuge PR, et al. Methylene blue: revisited. J Anaesthesiol Clin Pharmacol. 2010, 26(4):517-520.

• 溶解性： Soluble  in  DMSO、Ethanol、H2O

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	3.126 ml	15.632 ml	31.265 ml
  5 mM	0.625 ml	3.126 ml	6.253 ml
  10 mM	0.313 ml	1.563 ml	3.126 ml
  50 mM	0.063 ml	0.313 ml	0.625 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

• 24. [4.7] Tingyue Yu et al."Characteristics of Films Prepared from Wheat Gluten and Phenolic Extracts from Porphyra haitanensis and Its Application for Salmon Preservation."Foods.2024 Jan;13(15):2442

• 23. [IF=3.1] Shuyi Mi et al."HIF-1α/METTL1/m7G axis is involved in CRC response to hypoxia."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2023 Dec;:149385

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• 1. Chenghui Zheng, Zhenming Qi & Guoqiang Chen (2016) Silver sulfide quantum dots as sensitizer in self-cleaning of Bombyx mori silk fabrics with nano-titania, The Journal of The Textile Institute, 107:12, 1501-1510, DOI: 10.1080/00405000.2015.1128227

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本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *