S80892 |
(Z)-4-Hydroxytamoxifen |
源葉(MedMol) | 99% |
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- 產(chǎn)品描述: 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) induces CRISPR/Cas9 systems based on ER mediated nucleus translocation
- 靶點(diǎn): Estrogen receptor:3.3 nM (IC50);CRISPR/Cas9 ;EstrogenReceptor/ERR;Estrogen/progestogenReceptor
- 體內(nèi)研究:
4-Hydroxytamoxifen (0.2, 1 and 5 μg/day, p.o.) causes a dose-related decrease in uterine wet weight of immature rats. 4-Hydroxytamoxifen (6 μg/0.1 mL sesame oil/day, s.c.) effectively attenuates methamphetamine-induced nigrostriatal dopamine depletions in bothsexes of intact and gonadectomized C57BL/6 J mice. 4-Hydroxytamoxifen does not alter the dopamine content levels in the striatum
- 參考文獻(xiàn):
1. Jordan VC, et al. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol. 1977 Nov;75(2):305-16. 2. Davis KM, et al. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol. 2015 May;11(5):316-8. 3. Kuo YM, et al. 4-Hydroxytamoxifen attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in intact and gonadetomized mice. J Neurochem. 2003 Dec;87(6):1436-43. 4. Zhang J, et al. Drug Inducible CRISPR/Cas Systems. Comput Struct Biotechnol J. 2019;17:1171-1177.
- 溶解性: DMSO : 50 mg/mL (129.03 mM; ultrasonic and warming and heat to 60°C) Ethanol : 20 mg/mL (51.61 mM; Need ultrasonic)
- 保存條件: 2-8℃
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 2.581 ml 12.903 ml 25.806 ml 5 mM 0.516 ml 2.581 ml 5.161 ml 10 mM 0.258 ml 1.29 ml 2.581 ml 50 mM 0.052 ml 0.258 ml 0.516 ml
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輸入產(chǎn)品批號(hào):
本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系,公式為:
質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)