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• 產(chǎn)品描述： GSK429286A is a selective inhibitor of ROCK1 with an IC50 value of 14 nM.

• 靶點(diǎn)： ROCK1:14 nM (IC50);RSK:780 nM (IC50);p70S6K:1940 nM (IC50);ROCK

• 體內(nèi)研究：
  GSK429286A has 61% oral bioavailability in male Sprague-Dawley rats. Oral administration of GSK429286A at single doses of 3-30 mg/kg dramatically reduces mean arterial pressure in the spontaneously hypertensive rats (SHRs) in a dose-dependent manner, with a maximum decrease of 50 mmHg after approximately 2 hours treatment at dose of 30 mg/kg

• 參考文獻(xiàn)：
  1. Goodman KB et al Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50(1):6-9. 2. Nichols RJ et al Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23;424(1):47-60.

• 溶解性： DMSO  :  ≥  51  mg/mL  (117.95  mM)

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.313 ml	11.564 ml	23.128 ml
  5 mM	0.463 ml	2.313 ml	4.626 ml
  10 mM	0.231 ml	1.156 ml	2.313 ml
  50 mM	0.046 ml	0.231 ml	0.463 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *