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• 產(chǎn)品描述： Purvalanol A is a potent CDK inhibitor, which inhibits cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, cdk4-cyclin D1, and cdk5-p35 with IC50s of 4, 70, 35, 850, 75 nM, resepctively.

• 靶點(diǎn)： cdc2-cyclin B:4 nM (IC50);cdk2-cyclin E:35 nM (IC50);cdk2-cyclin A:70 nM (IC50);cdk4-cyclin D1:850 nM (IC50);cdk5-p35:75 nM (IC50);erk1:9000 nM (IC50);Apoptosis;?CDK;?Autophagy

• 參考文獻(xiàn)：
  1. Gray NS, et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. 2. Bain J, et al. The specificities of protein kinase inhibitors: an update. Biochem J. 2003 Apr 1;371(Pt 1):199-204. 3. Villerbu N, et al. Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. Int J Cancer. 2002 Feb 20;97(6):761-9.

• 溶解性： DMSO  :  ≥  50  mg/mL  (128.57  mM)

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.571 ml	12.857 ml	25.714 ml
  5 mM	0.514 ml	2.571 ml	5.143 ml
  10 mM	0.257 ml	1.286 ml	2.571 ml
  50 mM	0.051 ml	0.257 ml	0.514 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *