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• 產(chǎn)品描述：

  PX-478 is an orally active HIF-1α inhibitor with potent antitumor activities. PX-478 can cross the blood-brain barrier

• 靶點(diǎn)： HIF-1α;HIF/HIFProlyl-Hydroxylase;?HIF;?Autophagy

• 體內(nèi)研究：
  PX-478 is administered to mice with congenital HO (Nfatc1-Cre/caACVR1fl/fl) every other day starting from birth for 2 wk. Treated mice have significantly less ectopic bone at the ankle joints compared with mutant mice treated with vehicle (6.8 mm3?vs. 2.2 mm3, P<0.01)

• 參考文獻(xiàn)：
  1. Palayoor ST, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123(10):2430-2437. 2. Agarwal S, et al. Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E338-47.

• 溶解性： DMSO  :  100  mg/mL  (253.73  mM;  Need  ultrasonic)    H2O  :  ≥  35  mg/mL  (88.81  mM)

• 保存條件： 2-8℃，氮?dú)獗４?

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.537 ml	12.686 ml	25.372 ml
  5 mM	0.507 ml	2.537 ml	5.074 ml
  10 mM	0.254 ml	1.269 ml	2.537 ml
  50 mM	0.051 ml	0.254 ml	0.507 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *