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• 產(chǎn)品描述： SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM.

• 靶點(diǎn)： ROCK-II:3 nM (IC50);ROCK-I:56 nM (IC50);ROCK;?Autophagy

• 體內(nèi)研究：
  ExVivo: Pharmacology studies shows that SR-3677 is efficacious in both, increasing ex vivo aqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation. Continuous exposure of 25 μM SR-3677 increases the outflow facility by 60% at 1 h perfusion, increasing to 70–80% for the 2–5 h time points

• 參考文獻(xiàn)：
  1. Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5.

• 溶解性： DMSO  :  100  mg/mL  (244.83  mM;  Need  ultrasonic)

• 保存條件： RT

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.448 ml	12.241 ml	24.483 ml
  5 mM	0.49 ml	2.448 ml	4.897 ml
  10 mM	0.245 ml	1.224 ml	2.448 ml
  50 mM	0.049 ml	0.245 ml	0.49 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *