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• 產(chǎn)品描述： SAR7334是一種新型，高效且可生物利用的TRPC6通道抑制劑。SAR7334在膜片鉗實(shí)驗(yàn)中阻斷了TRPC6電流，IC50為7.9 nM

• 靶點(diǎn)： TPRC6(Cell-free assay):7.9nM;TRP/TRPVChannel

• 體外研究：
  SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca(2+) in?ux into cells with IC50s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected..SAR7334 suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice

• 體內(nèi)研究：
  Pharmacokinetic studies of SAR7334 demonstrates that the compound was suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)

• 細(xì)胞實(shí)驗(yàn)： Cell lines: HEK cells Concentrations: '-- Incubation Time: 10min Method: The cells are rinsed and incubated with standard extracellular solution supplemented with different concentrations of the test compound or vehicle for 10 min.

• 動物實(shí)驗(yàn)： Animal Models: Sprague Dawley rat Dosages: 10mg/kg Administration: oral

• 參考文獻(xiàn)：
  1. Maier T,et al.Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol.2015;172(14):3650-60

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.718 ml	13.592 ml	27.183 ml
  5 mM	0.544 ml	2.718 ml	5.437 ml
  10 mM	0.272 ml	1.359 ml	2.718 ml
  50 mM	0.054 ml	0.272 ml	0.544 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *