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• 產(chǎn)品描述： Senicapoc (ICA-17043) is a potent and selective?Gardos channel?(Ca2+-activated K+?channel;?KCa3.1) blocker with an?IC50?of 11 nM. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an?IC50?value of 11 nM and inhibits RBC dehydration with?IC50?of 30 nM

• 靶點(diǎn)： IC50: 11 nM (Gardos channel);PotassiumChannel

• 體內(nèi)研究：
  ICA-17043?(10 mg/kg, p.o.) administration produces a significant decrease in Gardos channel activity measured at day 11 and 21 and is associated with a corresponding increase in red cell K+?content without changes in Na+?content. ICA-17043 (10 mg/kg, twice a day) induces a significant increase in Hct after 11 days of dosing in the SAD mouse. Senicapoc (30 mg/kg, p.o.) reduces airway hyperresponsiveness, eosinophil numbers in bronchoalveolar lavage taken 48 hours post-allergen challenge, and vascular remodelling in the sheep.

• 參考文獻(xiàn)：
  1. Stocker JW, et al. ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood. 2003 Mar 15;101(6):2412-8. 2. Van Der Velden J, et al. K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma. PLoS One. 2013 Jun 24;8(6):e66886.

• 溶解性： Soluble  in  DMSO

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	3.093 ml	15.463 ml	30.926 ml
  5 mM	0.619 ml	3.093 ml	6.185 ml
  10 mM	0.309 ml	1.546 ml	3.093 ml
  50 mM	0.062 ml	0.309 ml	0.619 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *