• 產(chǎn)品描述： Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate,N-acetylhomotaurinate)是一種合成化合物，具有和氨基酸神經(jīng)轉(zhuǎn)運體GABA、氨基酸神經(jīng)調(diào)質(zhì)taurine類似的化學(xué)結(jié)構(gòu)。

• 靶點： GABAReceptor

• 體內(nèi)研究：
  Acamprosate is absorbed via the gastrointestinal tract, with pharmacokinetic linearity in terms of dose and time. Absolute bioavailability of acamprosate under fasting conditions is approximately 11%. After food intake, bioavailability decreases by approximately 20%, but this decrease lacks clinical significance. Steady-state plasma concentrations of acamprosate are reached within 5 days of dosing and the terminal half-life ranges from 20–33 hours following the standard 2 × 333 dosing regime. Plasma protein binding is negligible. Acamprosate is not metabolized in the liver and is excreted unchanged in the urine. Acamprosate may have neuroprotective effects. Acamprosate appears to work by normalizing the dysregulation of NMDA-mediated glutamatergic neurotransmission that occurs during chronic alcohol consumption and withdrawal, and thus attenuates one of the physiological mechanisms that may prompt relapse

• 參考文獻：
  1.Barbara J Mason, et al. CNS Neurol Disord Drug Targets. 2010, 9(1): 23–32.

• 溶解性： Soluble  in  H2O

• 保存條件： RT

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.497 ml	12.485 ml	24.97 ml
  5 mM	0.499 ml	2.497 ml	4.994 ml
  10 mM	0.25 ml	1.249 ml	2.497 ml
  50 mM	0.05 ml	0.25 ml	0.499 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *