• 產(chǎn)品描述： Aftin-4 is an Amyloid-β42 (Aβ42) inducer

• 靶點(diǎn)： Amyloid-β;BetaAmyloid;?Gamma-secretase

• 體外研究：
  Aftin-4 selectively and potently increases Aβ1-42 in N2a cells, primary neurons, and brain lysates, with an EC50 value around 30 μM

• 體內(nèi)研究：
  Aftin-4 increases Aβ1-42?levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD). Aftin-4 is administered at increasing doses, between 3 and 20 nmol/mouse, into the lateral ventricle and animals are sacrificed at various time points, between 3 to 14 days after injection. The hippocampus is dissected out the contents in Aβ1-40?or Aβ1-42?is determined using a mouse ELISA assay. Aftin-4 dose-dependently and significantly increases Aβ1-42?content, up to +216% at the highest dose tested

• 參考文獻(xiàn)：
  1. Meunier J, et al. Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative. J Alzheimers Dis. 2015;44(2):507-24.

• 溶解性： Soluble  in  DMSO

• 保存條件： -20°C

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.714 ml	13.569 ml	27.139 ml
  5 mM	0.543 ml	2.714 ml	5.428 ml
  10 mM	0.271 ml	1.357 ml	2.714 ml
  50 mM	0.054 ml	0.271 ml	0.543 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *