• 產(chǎn)品描述： CMP8, a selective ligand for estrogen receptor, binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 exhibits IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively

• 靶點(diǎn)： MGERα:29 nM (IC50);MGRERα:41 nM (IC50);hERα:1100 nM (IC50);hERβ:2200 nM (IC50);EstrogenReceptor/ERR;?Estrogen/progestogenReceptor

• 體內(nèi)研究：
  CMP8 is dosed in male Balb-c mice (4 mg/kg, i.p). In mammalian cells, the plasma concentration after 4 h is 1.5-fold its EC50. It has a Cmax of 0.5 μM after 30 min.

• 參考文獻(xiàn)：
  1. Miyazaki Y, et al. Destabilizing domains derived from the human estrogen receptor. J Am Chem Soc. 2012 Mar 7;134(9):3942-5.
  2. Kinzel O, et al. A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies. J Med Chem. 2006 Sep 7;49(18):5404-7.

• 溶解性： Soluble  in  DMSO

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	1.894 ml	9.468 ml	18.936 ml
  5 mM	0.379 ml	1.894 ml	3.787 ml
  10 mM	0.189 ml	0.947 ml	1.894 ml
  50 mM	0.038 ml	0.189 ml	0.379 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *