• 產(chǎn)品描述： DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation

• 靶點： p70S6K;Proteasome

• 體外研究：
  DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells. DD1 induces cell cycle arrest at G2/M phase and apoptosis. DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation. DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates

• 參考文獻：
  1. Marion Piedfer, et al. p70S6 kinase is a target of the novel proteasome inhibitor 3,3'-diamino-4'-methoxyflavone during apoptosis in human myeloid tumor cells. Biochim Biophys Acta. 2013 Jun;1833(6):1316-28.

• 溶解性： DMSO

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	3.542 ml	17.712 ml	35.424 ml
  5 mM	0.708 ml	3.542 ml	7.085 ml
  10 mM	0.354 ml	1.771 ml	3.542 ml
  50 mM	0.071 ml	0.354 ml	0.708 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *